Publications

20162015201420132012

2016:

Gross C, Yao X, Engel T, Tiwari D, Xing L, Rowley S, Danielson SW, Thomas KT, Jimenez-Mateos EM, Schroeder LM, Pun RY, Danzer SC, Henshall DC, Bassell GJ. MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset. Cell Rep. 2016 Sep 27;17(1):37-45.  doi: 10.1016/j.celrep.2016.08.074. PMID27681419 

Sebastián-Serrano Á, Engel T, de Diego-García L, Olivos-Oré LA, Arribas-Blázquez M, Martínez-Frailes C, Pérez-Díaz C, Millán JL, Artalejo AR, Miras-Portugal MT,Henshall DC, Díaz-Hernández M. Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation. Hum Mol Genet. 2016 Jul 27. pii: ddw248.  PMID27466191

Fischer W, Franke H, Krügel U, Müller H, Dinkel K, Lord B, Letavic MA, Henshall DC, Engel T. Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models. PLoS One. 2016 Jun 9;11(6):e0156468. doi: 10.1371/journal.pone.0156468. eCollection 2016. PMID27281030

Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, Sanz-Rodriguez A, Olivos-Oré LA, Artalejo AR, Alves M, Letavic M, Miras-Portugal MT, Conroy RM, Delanty N, Farrell MA, O’Brien DF, Bhattacharya A, Engel T, Henshall DC. Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.  J Neurosci. 2016 Jun 1;36(22):5920-32.            doi: 10.1523/JNEUROSCI.4009-15.2016. PMID27251615

Cattani AA, Allene C, Seifert V, Rosenow F, Henshall DC, Freiman TM. Involvement of microRNAs in epileptogenesis. Epilepsia. 2016 Jul;57(7):1015-26. doi: 10.1111/epi.13404. Epub 2016 May 21. Review. PMID: 27207608

D’Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH. Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci. 2016 Apr 20;36(16):4564-78. doi: 10.1523/JNEUROSCI.3780-15.2016. PMID 27098698

Mooney C, Becker BA, Raoof R, Henshall DC .EpimiRBase: a comprehensive database of microRNA-epilepsy associations. Bioinformatics. 2016 May 1;32(9):1436-8. doi: 10.1093/bioinformatics/btw008. Epub 2016 Jan 8. PMID 26748106

2015:

Mooney C, Raoof R, El-Naggar H, Sanz-Rodriguez A, Jimenez-Mateos EM, Henshall DC. High Throughput qPCR Expression Profiling of Circulating MicroRNAs Reveals Minimal Sex- and Sample Timing-Related Variation in Plasma of Healthy Volunteers.  PLoS One. 2015 Dec 23;10(12):e0145316. doi: 10.1371/journal.pone.0145316. eCollection 2015.   PMID: 26699132      

Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, Mooney CM, Mooney C, Lugara E, Morgan J, Langa E, Jimenez-Pacheco A, Silva LF, Mesuret G, Boison D, Miras-Portugal MT, Letavic M, Artalejo AR, Bhattacharya A, Diaz-Hernandez M, Henshall DC, Engel T. microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.           Sci Rep. 2015 Dec 3;5:17486. doi: 10.1038/srep17486.     PMID: 26631939 

Engel T, Alves M, Sheedy C, Henshall DC. .
ATPergic signalling during seizures and epilepsy. 
Neuropharmacology. 2016 May;104:140-53. doi: 10.1016/j.neuropharm.2015.11.001. Epub 2015 Nov 6.     PMID: 26549853

Eva M. Jimenez-Mateos, Rana Raoof, Hani ElNaggar, Norman Delanty, Robert J. Forster and David C. Henshall .
Direct, non-amplified detection of microRNA-134 in plasma from epilepsy patients 
RSC Adv., 2015,5, 90071-90078 DOI: 10.1039/C5RA16352H

Henshall DC, Kobow K .
Epigenetics and Epilepsy. 
Cold Spring Harb Perspect Med. 2015 Oct 5;5(12). pii: a022731. doi: 10.1101/cshperspect.a022731.     PMID: 26438606

Rodriguez-Alvarez N, Jimenez-Mateos EM, Dunleavy M, Waddington JL, Boylan GB, Henshall DC. .
Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice 
Neurobiol Dis. 2015 Nov;83:100-14. doi: 10.1016/j.nbd.2015.08.023. Epub 2015 Sep 1.   PMID: 26341542

Diviney M, Reynolds JP, Henshall DC .
Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice. 
Epilepsy Behav. 2015 Oct;51:191-8. doi: 10.1016/j.yebeh.2015.07.038. Epub 2015 Aug 24 PMID: 26291773

Reschke CR, Henshall DC .
microRNA and Epilepsy. 
Adv Exp Med Biol. 2015;888:41-70. doi: 10.1007/978-3-319-22671-2_4.   PMID: 26663178

Henshall DC, Engel T.  P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus. Epilepsy Behav. 2015 Aug;49:8-12. doi: 10.1016/j.yebeh.2015.02.031. Epub 2015 Apr 3.     PMID: 25843343      

Reynolds JP, Miller-Delaney SF, Jimenez-Mateos EM, Sano T, McKiernan RC, Simon RP, Henshall DC .
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning 
Front Neurol. 2015 Mar 10;6:46. doi: 10.3389/fneur.2015.00046. eCollection 2015.     PMID: 25806020

Miller-Delaney SF, Bryan K, Das S, McKiernan RC, Bray IM, Reynolds JP, Gwinn R, Stallings RL, Henshall DC. Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy. Brain. 2015 Mar;138(Pt 3):616-31. doi: 10.1093/brain/awu373. Epub 2014 Dec 30.     PMID: 25552301

Brennan GP, Jimenez-Mateos EM, Sanz-Rodriguez A, Mooney CM, Tzivion G, Henshall DC, Engel T. Overexpression of 14-3-3ζ Increases Brain Levels of C/EBP Homologous Protein CHOP. J Mol Neurosci. 2015 Jun;56(2):255-62. doi: 10.1007/s12031-015-0510-0. Epub 2015 Feb 1     PMID: 25854777

D’Orsi B, Kilbride SM, Chen G, Perez Alvarez S, Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH . Bax regulates neuronal Ca2+ homeostasis 
J Neurosci. 2015 Jan 28;35(4):1706-22. doi: 10.1523/JNEUROSCI.2453-14.2015.    PMID: 25632145

2014:

Dávila D, Jiménez-Mateos EM, Mooney CM, Velasco G, Henshall DC, Prehn JH. Mol Hsp27 binding to the 3′UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury – a novel cytoprotective mechanism. Biol Cell. 2014 Sep 3. pii: mbc.E13-08-0495.

Jimenez-Mateos EM, Engel T, Merino-Serrais P, Fernaud-Espinosa I, Rodriguez-Alvarez N, Reynolds J, Reschke CR, Conroy RM, McKiernan RC, deFelipe J, Henshall DCAntagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. Brain Struct Funct. 2015 Jul;220(4):2387-99. doi: 10.1007/s00429-014-0798-5. Epub 2014 May 30. PMID 24874920

Mesuret G, Engel T, Hessel EV, Sanz-Rodriguez A, Jimenez-Pacheco A, Miras-Portugal MT, Diaz-Hernandez M, Henshall DCP2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage. CNS Neurosci Ther. 2014 Jun;20(6):556-64. doi: 10.1111/cns.12272. Epub 2014 Apr 21. PMID24750893

Nolan K, Mitchem MR, Jimenez-Mateos EM, Henshall DC, Concannon CG, Prehn JH. Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition. J Mol Neurosci. 2014 Jun;53(2):231-41. doi: 10.1007/s12031-014-0290-y. Epub 2014 Apr 4. PMID24696165

Henshall DCMicroRNA and epilepsy: profiling, functions and potential clinical applications. Curr Opin Neurol. 2014 Apr;27(2):199-205. doi: 10.1097/WCO.0000000000000079. Review. PMID24553459

Dunleavy M, Schindler CK, Shinoda S, Crilly S, Henshall DCNeurogenic function in rats with unilateral hippocampal sclerosis that experienced early-life status epilepticus. Int J Physiol Pathophysiol Pharmacol. 2014 Dec 15;6(4):199-208. eCollection 2014PMID: 25755841 

2013:

Henshall DC, Diaz-Hernandez M, Miras-Portugal MT, Engel T. P2X receptors as targets for the treatment of status epilepticus.  Front Cell Neurosci. 2013 Nov 26;7:237. doi: 10.3389/fncel.2013.00237. Review. PMID 24324404

Henshall DC. MicroRNAs in the pathophysiology and treatment of status epilepticus. Front Mol Neurosci. 2013 Nov 12;6:37. doi: 10.3389/fnmol.2013.00037. eCollection 2013. Review. PMID: 24282394

Henshall DCAntagomirs and microRNA in status epilepticus. Epilepsia. 2013 Sep;54 Suppl 6:17-9. doi: 10.1111/epi.12267. Review. PMID: 24001063

Miller-Delaney SF, Das S, Stallings RL, Henshall DCInvestigating gene promoter methylation in a mouse model of status epilepticus. Methods Mol Biol. 2013;1067:87-101. doi: 10.1007/978-1-62703-607-8_7. PMID: 23975788

Henshall DC, Engel T.  Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts. Front Cell Neurosci. 2013 Jul 16;7:110. doi: 10.3389/fncel.2013.00110. eCollection 2013.  PMID: 23882182

Jimenez-Pacheco A, Mesuret G, Sanz-Rodriguez A, Tanaka K, Mooney C, Conroy R, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC, Engel T.  Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079.  Epilepsia. 2013 Sep;54(9):1551-61. doi: 10.1111/epi.12257. Epub 2013 Jun 28.  PMID: 23808395

Moran C, Sanz-Rodriguez A, Jimenez-Pacheco A, Martinez-Villareal J, McKiernan RC, Jimenez-Mateos EM, Mooney C, Woods I, Prehn JH, Henshall DC, Engel T.  Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death. Cell Death Dis. 2013 Apr 25;4:e606. doi: 10.1038/cddis.2013.136.  PMID: 23618904

Torres-Peraza JF, Engel T, Martín-Ibáñez R, Sanz-Rodríguez A, Fernández-Fernández MR, Esgleas M, Canals JM, Henshall DC, Lucas JJ.  Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.  Brain. 2013 Apr;136(Pt 4):1161-76. doi: 10.1093/brain/awt044. Epub 2013 Mar 20.  PMID: 23518711

Jimenez-Mateos EM, Henshall DC.  Epilepsy and microRNA.  Neuroscience. 2013 May 15;238:218-29. doi: 10.1016/j.neuroscience.2013.02.027. Epub 2013 Feb 26. Review. PMID23485811

Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O’Brien DF, Prehn JH, Lucas JJ, Henshall DCCHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures. Brain. 2013 Feb;136(Pt 2):577-92. doi: 10.1093/brain/aws337. Epub 2013 Jan 29. PMID: 23361066

Brennan GP, Jimenez-Mateos EM, McKiernan RC, Engel T, Tzivion G, Henshall DC.  Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.  PLoS One. 2013;8(1):e54491. doi: 10.1371/journal.pone.0054491. Epub 2013 Jan 24.  PMID: 23359526

Caballero-Caballero A, Engel T, Martinez-Villarreal J, Sanz-Rodriguez A, Chang P, Dunleavy M, Mooney CM, Jimenez-Mateos EM, Schindler CK, Henshall DCMitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain.  J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.  PMID: 23278239

Michalak Z, Sano T, Engel T, Miller-Delaney SF, Lerner-Natoli M, Henshall DC.  Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice.  Epilepsy Res. 2013 Feb;103(2-3):167-79.  doi: 10.1016/j.eplepsyres.2012.10.006.  Nov 20.  PMID: 23182415

Dunleavy M, Provenzano G, Henshall DC, Bozzi Y.  Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice.  J Mol Neurosci. 2013 Jan;49(1):202-10. doi: 10.1007/s12031-012-9927- Nov 29.  PMID: 23188702

Michalak Z, Sano T, Engel T, Miller-Delaney SF, Lerner-Natoli M, Henshall DC.   Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice.  Epilepsy Res. 2013 Feb;103(2-3):167-79. doi: 0.1016/j.eplepsyres.2012.10.006. Epub 2012 Nov 20.  PMID23182415

2012:

Engel T, Jimenez-Pacheco A, Miras-Portugal MT, Diaz-Hernandez M, Henshall DCP2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. Int J Physiol Pathophysiol Pharmacol. 2012;4(4):174-87. Epub 2012 Dec 26. PMID: 23320131

Heverin M, Engel T, Meaney S, Jimenez-Mateos EM, Al-Saudi R, Henshall DC.  Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice. Brain Res. 2012 Oct 22;1480:81-90. doi: 10.1016/j.brainres.2012.08.018. Epub 2012 Aug 17.  PMID: 22921849

Michalak Z, Lebrun A, Di Miceli M, Rousset MC, Crespel A, Coubes P, Henshall DC, Lerner-Natoli M, Rigau V.  IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption.  J Neuropathol Exp Neurol. 2012 Sep;71(9):826-38. doi: 10.1097/NEN.0b013e31826809a6.  PMID: 22878666

Heverin M, Brennan GP, Koehler CJ, Treumann A, Henshall DC.  Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus.   Int J Physiol Pathophysiol Pharmacol. 2012;4(2):74-83. Epub 2012 Jun 23.  PMID: 22837806

Henshall DC, Meldrum BS.  Cell death and survival mechanisms after single and repeated brief seizures.  In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper’s Basic Mechanism of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US);  PMID: 22787605

McKiernan RC, Jimenez-Mateos EM, Sano T, Bray I, Stallings RL, Simon RP, Henshall DC.  Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death.   Exp Neurol. 2012 Oct;237(2):346-54. doi: 10.1016/j.expneurol.2012.06.029. PMID: 22771761 

Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O’Tuathaigh C, Waddington JL, Prenter S, Delanty N, Farrell MA, O’Brien DF, Conroy RM, Stallings RL, DeFelipe J, Henshall DC.  Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.  Nat Med. 2012 Jul;18(7):1087-94. doi: 10.1038/nm.2834.  PMID: 22683779

McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O’Brien D, Meller R, Simon RP, Stallings RL, Henshall DC.  Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.   PLoS One. 2012;7(5):e35921. doi: 10.1371/journal.pone.0035921. Epub 2012 May 15.   PMID: 22615744

Sano T, Reynolds JP, Jimenez-Mateos EM, Matsushima S, Taki W, Henshall DCMicroRNA-34a upregulation during seizure-induced neuronal death.  Cell Death Dis. 2012 Mar 22;3:e287. doi: 10.1038/cddis.2012.23. PMID: 22436728

Kilany A, Raouf ER, Gaber AA, Aloush TK, Aref HA, Anwar M, Henshall DC, Abdulghani MO.  Elevated serum Bcl-2 in children with temporal lobe epilepsy.   Seizure. 2012 May;21(4):250-3. doi: 10.1016/j.seizure.2012.01.004. Epub 2012 Feb 23. PMID: 22365585

Miller-Delaney SF, Das S, Sano T, Jimenez-Mateos EM, Bryan K, Buckley PG, Stallings RL,Henshall DCDifferential DNA methylation patterns define status epilepticus and epileptic tolerance. J Neurosci. 2012 Feb 1;32(5):1577-88. doi: 10.1523/JNEUROSCI.5180-11.2012. PMID: 22302800

Engel T, Gomez-Villafuertes R, Tanaka K, Mesuret G, Sanz-Rodriguez A, Garcia-Huerta P, Miras-Portugal MT, Henshall DC, Diaz-Hernandez M.  Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice. FASEB J. 2012 Apr;26(4):1616-28. doi: 10.1096/fj.11-196089. Epub 2011 Dec 23.